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bip grp78 inhibitor  (MedChemExpress)


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    MedChemExpress bip grp78 inhibitor
    Bip Grp78 Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/bip grp78 inhibitor/product/MedChemExpress
    Average 93 stars, based on 2 article reviews
    bip grp78 inhibitor - by Bioz Stars, 2026-02
    93/100 stars

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    BAF60c interacts with GRP78 (A) Co-IP of HEK293T cells overexpressing BAF60c-HA and GRP78-FLAG. (B) HEK293T cells were co-transfected with BAF60c-GFP and GRP78-RFP plasmids for 24 h and followed by laser scanning confocal microscopy to observe the colocalization of BAF60c and GRP78. Scale bars, 20 μm.

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet: BAF60c interacts with GRP78 (A) Co-IP of HEK293T cells overexpressing BAF60c-HA and GRP78-FLAG. (B) HEK293T cells were co-transfected with BAF60c-GFP and GRP78-RFP plasmids for 24 h and followed by laser scanning confocal microscopy to observe the colocalization of BAF60c and GRP78. Scale bars, 20 μm.

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Co-Immunoprecipitation Assay, Transfection, Confocal Microscopy

    BAF60c regulates GRP78 expression in fish (A) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in macrophage. (B) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in hepatocyte. (C) Relative mRNA expression of BAF60c and GRP78 after overexpression of BAF60c for 24 h in hepatocyte. (D) Relative mRNA expression of BAF60c and GRP78 after BiP treatment for 4 h with different concentrations in macrophages. (E) Protein level of BAF60c after 10 μM BiP treatment for 4 and 8 h in macrophages. (F) Relative mRNA expression of BAF60c and GRP78 after HM03 treatment for 4 h with different concentrations in macrophages. (G) Protein level of BAF60c after 10 μM HM03 treatment for 3 and 5 h in macrophages. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet: BAF60c regulates GRP78 expression in fish (A) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in macrophage. (B) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in hepatocyte. (C) Relative mRNA expression of BAF60c and GRP78 after overexpression of BAF60c for 24 h in hepatocyte. (D) Relative mRNA expression of BAF60c and GRP78 after BiP treatment for 4 h with different concentrations in macrophages. (E) Protein level of BAF60c after 10 μM BiP treatment for 4 and 8 h in macrophages. (F) Relative mRNA expression of BAF60c and GRP78 after HM03 treatment for 4 h with different concentrations in macrophages. (G) Protein level of BAF60c after 10 μM HM03 treatment for 3 and 5 h in macrophages. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Expressing, Over Expression

    Knockdown of GRP78 in macrophages and hepatocytes can reduce ER stress, inflammation, and fatty acid biosynthesis (A) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in macrophages. (B) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in macrophages. (C) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in macrophages. (D) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in hepatocytes. (E) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. (F) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in hepatocytes. (G) Relative mRNA expression of lipid metabolism-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet: Knockdown of GRP78 in macrophages and hepatocytes can reduce ER stress, inflammation, and fatty acid biosynthesis (A) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in macrophages. (B) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in macrophages. (C) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in macrophages. (D) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in hepatocytes. (E) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. (F) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in hepatocytes. (G) Relative mRNA expression of lipid metabolism-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Knockdown, Expressing

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet:

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Virus, Recombinant, Transfection, Sequencing, Plasmid Preparation, Software

    BAF60c interacts with GRP78 (A) Co-IP of HEK293T cells overexpressing BAF60c-HA and GRP78-FLAG. (B) HEK293T cells were co-transfected with BAF60c-GFP and GRP78-RFP plasmids for 24 h and followed by laser scanning confocal microscopy to observe the colocalization of BAF60c and GRP78. Scale bars, 20 μm.

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet: BAF60c interacts with GRP78 (A) Co-IP of HEK293T cells overexpressing BAF60c-HA and GRP78-FLAG. (B) HEK293T cells were co-transfected with BAF60c-GFP and GRP78-RFP plasmids for 24 h and followed by laser scanning confocal microscopy to observe the colocalization of BAF60c and GRP78. Scale bars, 20 μm.

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Co-Immunoprecipitation Assay, Transfection, Confocal Microscopy

    BAF60c regulates GRP78 expression in fish (A) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in macrophage. (B) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in hepatocyte. (C) Relative mRNA expression of BAF60c and GRP78 after overexpression of BAF60c for 24 h in hepatocyte. (D) Relative mRNA expression of BAF60c and GRP78 after BiP treatment for 4 h with different concentrations in macrophages. (E) Protein level of BAF60c after 10 μM BiP treatment for 4 and 8 h in macrophages. (F) Relative mRNA expression of BAF60c and GRP78 after HM03 treatment for 4 h with different concentrations in macrophages. (G) Protein level of BAF60c after 10 μM HM03 treatment for 3 and 5 h in macrophages. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet: BAF60c regulates GRP78 expression in fish (A) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in macrophage. (B) Relative mRNA expression of BAF60c and GRP78 after BAF60c-siRNA treatment for 36 h in hepatocyte. (C) Relative mRNA expression of BAF60c and GRP78 after overexpression of BAF60c for 24 h in hepatocyte. (D) Relative mRNA expression of BAF60c and GRP78 after BiP treatment for 4 h with different concentrations in macrophages. (E) Protein level of BAF60c after 10 μM BiP treatment for 4 and 8 h in macrophages. (F) Relative mRNA expression of BAF60c and GRP78 after HM03 treatment for 4 h with different concentrations in macrophages. (G) Protein level of BAF60c after 10 μM HM03 treatment for 3 and 5 h in macrophages. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Expressing, Over Expression

    Knockdown of GRP78 in macrophages and hepatocytes can reduce ER stress, inflammation, and fatty acid biosynthesis (A) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in macrophages. (B) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in macrophages. (C) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in macrophages. (D) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in hepatocytes. (E) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. (F) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in hepatocytes. (G) Relative mRNA expression of lipid metabolism-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet: Knockdown of GRP78 in macrophages and hepatocytes can reduce ER stress, inflammation, and fatty acid biosynthesis (A) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in macrophages. (B) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in macrophages. (C) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in macrophages. (D) Relative mRNA expression of grp78 after GRP78-siRNA treatment for 36 h in hepatocytes. (E) Relative mRNA expression of ER stress-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. (F) Relative mRNA expression of inflammatory genes after GRP78-siRNA treatment for 36 h in hepatocytes. (G) Relative mRNA expression of lipid metabolism-related genes after GRP78-siRNA treatment for 36 h in hepatocytes. Data are represented as mean ± SEM (n = 3) and were analyzed using independent t test. The “∗” means a significant difference (p < 0.05), and “∗∗” means a highly significant difference (p < 0.01).

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Knockdown, Expressing

    Journal: iScience

    Article Title: Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish

    doi: 10.1016/j.isci.2023.108207

    Figure Lengend Snippet:

    Article Snippet: GRP78 agonist (Bip inducer X; MCE) and GRP78 inhibitor (HM03; MCE) were incubated with a concentration of 10 μM for different time points.

    Techniques: Virus, Recombinant, Transfection, Sequencing, Plasmid Preparation, Software

    Fig. 6 Model of OTUDin3 inhibits NSCLC through targeting deubiquitylase OTUD3. OTUDin3 inhibits the deubiquitinating activity of OTUD3, resulting in enhanced ubiquitination of GRP78 and a consequent decrease in GRP78 protein levels, thereby inducing apoptosis of NSCLC cells. By Figdraw.

    Journal: Cell death & disease

    Article Title: Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer.

    doi: 10.1038/s41419-023-05900-2

    Figure Lengend Snippet: Fig. 6 Model of OTUDin3 inhibits NSCLC through targeting deubiquitylase OTUD3. OTUDin3 inhibits the deubiquitinating activity of OTUD3, resulting in enhanced ubiquitination of GRP78 and a consequent decrease in GRP78 protein levels, thereby inducing apoptosis of NSCLC cells. By Figdraw.

    Article Snippet: The cells were treated with different concentrations of OTUDin3 or an equal volume of DMSO for 40 h. Cells were lysed with RIPA lysis buffer after treated with 20 μM of the proteasome inhibitor MG132 (Calbiochem) for 8 h and incubated with anti-GRP78 antibody for 6 h and protein A/G agarose beads (Santa Cruz) for a further 8 h at 4 °C.

    Techniques: Activity Assay, Ubiquitin Proteomics